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CITEgeist: Accurate deconvolution of spatial transcriptomics with same-slide proteomics reveals midkine as a secreted microenvironment modulator in ESR1 mutant breast cancer

2025-02-17

Abstract excerpt

<h4>Background</h4> Dysplastic tissue architecture in estrogen receptor-positive (ER+) breast cancer across therapy-naïve and therapy-exposed cancer tissues presents unique challenges in the analysis of spatial transcriptomics. Many tools for deconvolution are developed on well-structured tissue architectures such as the 10x Genomics mouse hippocampus dataset. Spatial transcriptomics analysis could offer valuable...

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Literature Corpus work: a5ed1121-b78b-5e79-97f1-917fa7d27300
DOI: 10.1101/2025.02.15.638331

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