Article

NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

2022-07-12

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease and no preventive or curative therapy is available. CADASIL is caused by mutations in the NOTCH3 gene, resulting in a mutated NOTCH3 receptor, with aggregation of the NOTCH3 extracellular domain (ECD) around vascular smooth muscle cells. In this st...

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Literature Corpus work: a5e940b4-c725-590f-80e7-f110f6a5380e
DOI: 10.1101/2022.07.11.499563

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NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse modelDOI 10.1101/2022.07.11.499563Read

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