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A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma

30 Oct 2015

Abstract excerpt

Clear cell renal cell carcinomas (ccRCCs) display divergent clinical behaviours. Molecular markers might improve risk stratification of ccRCC. Here we use, based on genome-wide CpG methylation profiling, a LASSO model to develop a five-CpG-based assay for ccRCC prognosis that can be used with formalin-fixed paraffin-embedded specimens. The five-CpG-based classifier was validated in three independent sets from...

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PMID: 26515236
DOI: 10.1038/ncomms9699

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