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Article

Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo.

Gene therapy - 1 Dec 2003

Wang Z, Ma H-I, Li J, Sun L, Zhang J, Xiao X

Abstract excerpt

Adeno-associated virus (AAV) is a promising gene vector based on a single-stranded (ss) DNA virus. Its transgene expression requires the conversion of ssDNA to double-stranded (ds) genome, a slow process responsible for the delayed transduction and occasional inefficiency. By mutating the inverte...

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Identifiers

PMID: 14625564
DOI: 10.1038/sj.gt.3302133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14625564-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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