Article

AAV vectors trigger DNA damage responses and STING-dependent inflammation in human CNS cells

2024-04-10

Abstract excerpt

<title>Abstract</title> <p>Adeno-associated viral (AAV) vector-based gene therapy is gaining foothold as a treatment option for a variety of genetic neurological diseases with encouraging clinical results. Nonetheless, dose-dependent toxicities and severe adverse events have emerged in recent clinical trials through mechanisms that remain unclear. We have modelled here the impact of AAV transduction in the contex...

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Literature Corpus work: 54680b47-8c33-5238-b3da-4417a9d58f10
DOI: 10.21203/rs.3.rs-4171795/v1

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