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Pazopanib Combined with Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

2025-07-31

Abstract excerpt

<h4>Background: </h4> While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high-risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi-targeted tyrosine kinase inhibitor, might enhance treatment efficacy through antiangio...

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Literature Corpus work
a5a18596-38b0-5140-8f0b-38b6c8af2296
DOI
10.22541/au.175394365.52830376/v1
Open publication

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