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Article

Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2020

Larrivee Casandra L, Feng Huijie, Quinn Josiah A, Shaw Vincent S, Leipprandt Jeffrey R, Demireva Elena Y, Xie Huirong, Neubig Richard R

Abstract excerpt

Neurodevelopmental disorder with involuntary movements (Online Mendelian Inheritance in Man: 617493) is a severe, early onset neurologic condition characterized by a delay in psychomotor development, hypotonia, and hyperkinetic involuntary movements. Heterozygous de novo mutations in the GNAO1 gene cause neurodevelopmental disorder with involuntary movements. Gα o, the gene product of GNAO1, is the alpha subunit...

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Identifiers

PMID: 31907305
DOI: 10.1124/jpet.119.262733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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