Article
The 1000 Chinese Pangenome empowers medical and population genetics.
Nature - 1 Jun 2026
Wang Yifei, Duan Zhongqu, Chen Dan, Shi Dandan, Ding Yi, Wang Zhibin, Li Baoqing, Wang Zhiyi, Guo Minmin, Yang Wen, Hou Junren, Chen Wenhao, Guo Yazhou, Wei Wenjie, Cao Yujie, Sun Xiwei, Bai Weiyang, Lu Mingdong, Qi Ting, Shen Xian, Yang Jian
Abstract excerpt
Pangenomes are revolutionizing our ability to resolve genomic regions with complex variations1. However, existing human pangenomes2,3, constrained by small sample sizes, provide limited utility for medical and population genetic applications. Here we generated 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed) with an average size of 2.98 Gb and a mean quality value of 46 as part of the...
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