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Comparative pangenomics of <i>Trypanosoma brucei</i> reveal host specialization is driven by targeted or segmental genome streamlining in human and equine-restricted lineages

2026-06-19

Abstract excerpt

How the eukaryotic parasite Trypanosoma brucei remodels its genome during host specialization remains a fundamental question in evolutionary biology. In contrast to the uniform, systemic gene loss seen in resident bacterial genomes, the structural variations driving niche restriction in extracellular pathogens are poorly defined. Here, we establish a high-resolution comparative structural pangenomic map of the T...

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Literature Corpus work
a52b1f2b-9691-5722-883d-55513ba823c6
DOI
10.64898/2026.06.15.732286
Open publication

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Comparative pangenomics of <i>Trypanosoma brucei</i> reveal host specialization is driven by targeted or segmental genome streamlining in human and equine-restricted lineagesDOI 10.64898/2026.06.15.732286
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