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Article

Population genomics reveals the origin and asexual evolution of human infective trypanosomes.

eLife - 26 Jan 2016

Weir William, Capewell Paul, Foth Bernardo, Clucas Caroline, Pountain Andrew, Steketee Pieter, Veitch Nicola, Koffi Mathurin, De Meeûs Thierry, Kaboré Jacques, Camara Mamadou, Cooper Anneli, Tait Andy, Jamonneau Vincent, Bucheton Bruno, Berriman Matt, MacLeod Annette

Abstract excerpt

Evolutionary theory predicts that the lack of recombination and chromosomal re-assortment in strictly asexual organisms results in homologous chromosomes irreversibly accumulating mutations and thus evolving independently of each other, a phenomenon termed the Meselson effect. We apply a population genomics approach to examine this effect in an important human pathogen, Trypanosoma brucei gambiense. We determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26809473
DOI: 10.7554/eLife.11473
PMCID: PMC4739771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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