Article

Persistent activation of interlinked Th2-airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic atopic asthmatics

2016-07-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Atopic asthma is a persistent disease characterized by intermittent wheeze and progressive loss of lung function. The disease is thought to be driven primarily by chronic aeroallergen-induced Th2-associated airways inflammation. However, the vast majority of atopics do not develop asthma-related wheeze, despite ongoing exposure to aeroallergens to which they are strongly sens...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a50a9aab-4003-51fe-a56c-f84a55289a54
DOI: 10.1101/063602

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Persistent activation of interlinked Th2-airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic atopic asthmaticsDOI 10.1101/063602Read

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopicsSemantic proximity Read

Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in AsthmaSemantic proximity Read

Transcriptomic analysis reveals diverse gene expression changes in airway macrophages during experimental allergic airway diseaseSemantic proximity Read

Integration of Airway Inflammation and Remodeling Mechanisms Specific to Eosinophilic Asthma Through Differential Co-Expression of Genes in Bronchial Brush Biopsy SamplesSemantic proximity Read

Allergen-responsive T helper type 2 cells revealed by high-dimensional profiling in allergen challenged human airwaysSemantic proximity Read

Single-cell RNA Sequencing Analysis of Sputum Cell Transcriptomes Reveals Pathways and Communication Networks That Contribute to the Pathogenesis of AsthmaSemantic proximity Read

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthmaSemantic proximity Read

Discovery of Novel Biomarker Candidates for Distinguishing Allergic Asthma from Non-Allergic Asthma via the Olink Proteomics PlatformSemantic proximity Read

Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populationsSemantic proximity Read

Identification of Novel Th2-Associated Genes in T Memory Responses to AllergensSemantic proximity Read

Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in childrenSemantic proximity Read

Transcriptomic Analysis Links Eosinophilic Esophagitis and Atopic DermatitisSemantic proximity Read