Article

A neural crest stem cell-like state drives nongenetic resistance to targeted therapy in melanoma

2020-12-16

Abstract excerpt

<h4>Summary</h4> The ability to predict the future behaviour of an individual cancer is crucial for precision cancer medicine and, in particular, for the development of strategies that prevent acquisition of resistance to anti-cancer drugs. Therapy resistance, which often develops from a heterogeneous pool of drug-tolerant cells known as minimal residual disease (MRD), is thought to mainly occur through acquisiti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f803217-b639-5302-9267-aa60f1a32da5
DOI: 10.1101/2020.12.15.422929

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A neural crest stem cell-like state drives nongenetic resistance to targeted therapy in melanomaDOI 10.1101/2020.12.15.422929Read

Mechanisms of Melanoma Progression and Treatment Resistance: Role of Cancer Stem-like CellsSemantic proximity Read

Nongenetic Mechanisms of Drug Resistance in MelanomaSemantic proximity Read

Reemergence of neural crest stem cell-like states in melanoma during disease progression and treatmentSemantic proximity Read

Cancer stem cells versus phenotype-switching in melanoma.Semantic proximity Read

Neural crest stem cells in melanoma developmentSemantic proximity Read

Tracking of Melanoma Cell Plasticity by Transcriptional ReportersSemantic proximity Read

How Neural Crest Transcription Factors Contribute to Melanoma Heterogeneity, Cellular Plasticity, and Treatment Resistance.Semantic proximity Read

Toward Minimal Residual Disease-Directed Therapy in Melanoma.Semantic proximity Read

Dissecting Mechanisms of Melanoma Resistance to BRAF and MEK Inhibitors Revealed Genetic and Non-Genetic Patient- and Drug-Specific Alterations and Remarkable Phenotypic PlasticitySemantic proximity Read

Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in MelanomaSemantic proximity Read

SOX2 empowers a rapid tumorigenic programme from the tumour-resistant population in the skinSemantic proximity Read

Targeting the ERK/MAPK Pathway in Cancer: Oncogenic Mechanisms, Therapeutic Resistance, and Emerging Gene-Based StrategiesSemantic proximity Read