Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment

24 Aug 2019

Abstract excerpt

Although cisplatin has been a pivotal chemotherapy drug in treating patients with various types of cancer for decades, drug resistance has been a major clinical impediment. In general, cisplatin exerts cytotoxic effects in tumor cells mainly through the generation of DNA-platinum adducts and subsequent DNA damage response. Accordingly, considerable effort has been devoted to clarify the resistance mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Genomics, phytochemicals, and oxidative stress
Share to Metal complexes synthesis and properties

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31450627
DOI: 10.3390/ijms20174136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to MicroenvironmentPMID 31450627Read ↗

Can Cisplatin Therapy Be Improved? Pathways That Can Be TargetedSemantic proximity Read ↗

Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapySemantic proximity Read ↗

Drug resistance mechanisms in cancers: Execution of pro-survival strategiesSemantic proximity Read ↗

Cisplatin resistance: Preclinical findings and clinical implicationsSemantic proximity Read ↗

Overview of tumor cell chemoresistance mechanisms.Semantic proximity Read ↗

Molecular Mechanisms for Targeting Metastatic Cancer Cells and to Overcome or Prevent Chemotherapy ResistanceSemantic proximity Read ↗

Ovarian Cancer—Insights into Platinum Resistance and Overcoming ItSemantic proximity Read ↗

Systems biology of cisplatin resistance: past, present and futureSemantic proximity Read ↗

The multi-molecular mechanisms of tumor-targeted drug resistance in precision medicineSemantic proximity Read ↗

The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor AgentsSemantic proximity Read ↗

Molecular mechanisms of cisplatin resistance in ovarian cancerSemantic proximity Read ↗

The role of microRNA in cisplatin resistance or sensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.