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Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system

2025-05-12

Abstract excerpt

Metabolic disorders could cause dysregulated glucose and lipid at the systemic level, but how inter-tissue/organ communications contribute to glucolipotoxicity is difficult to dissect in animal models. To solve this problem, myocardium and nerve tissues were modeled by 3D engineered heart tissues (EHTs) and neural organoids (NOs), which were co-cultured in a generalized medium with normal or elevated glucose/fatty...

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Literature Corpus work
a4a06e8f-4aa3-5df5-bed3-6371cde3e6cb
DOI
10.1101/2025.05.07.652597
Open publication

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Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture systemDOI 10.1101/2025.05.07.652597
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