Article

Identification of EPHB4 variants in dilated cardiomyopathy patients

2022-12-20

Abstract excerpt

Cardiac homeostasis relies on the appropriate provision of nutrients to the working myocardium. EPHB4 is required for the maintenance of vascular integrity and correct fatty acid transport uptake in the heart via regulating the caveolar trafficking of the fatty acid receptor CD36. In the mouse, endothelial specific loss-of-function of the receptor EphB4, or its ligand ephrin-B2, induces Dilated Cardiomyopathy (DCM...

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Literature Corpus work: a487d367-c99a-5856-8e14-c2c18bb471ac
DOI: 10.1101/2022.12.16.22283442

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