Expert-Guided Supervised Annotation of Erythroid Differentiation in Single-Cell RNA-seq

Abstract excerpt

Accurate annotation of intermediate cell states remains a major challenge in single-cell RNA sequencing (scRNA-seq), particularly in continuous differentiation systems such as erythropoiesis. Existing reference-based methods often lack the resolution required to distinguish early and transitional erythroid progenitors and may generalise poorly across datasets and modalities. Here, we present a supervised framework...

Topics

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• CCAAT-Enhancer-Binding Proteins
• Cellular Senescence
• Erythrocyte Function and Pathophysiology
• Erythropoietin
• Gene Editing
• Hematopoiesis
• Hematopoietic Stem Cells
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

a46b7d52-da47-5cdd-9af3-92161952ea94

DOI

10.64898/2026.06.05.730313