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Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerating Healing

2026-01-30

Abstract excerpt

Responses to cutaneous injury differ fundamentally across developmental stages. During early human gestation, when the fetus is less than 24 weeks old, wounds are capable of restoring normal tissue architecture without forming fibrotic scars. In con-trast, postnatal and adult injuries typically resolve through the process of fibrosis. This divergence reflects coordinated differences in epidermal and dermal compart...

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Identifiers and source

Literature Corpus work
a42ff109-29e5-539a-8f0d-b313cdc9665b
DOI
10.20944/preprints202601.2331.v1
Open publication

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