Article

Gac is a transcriptional repressor of the Lyme disease spirochete’s OspC virulence-associated surface protein

2022-11-09

Abstract excerpt

The OspC outer-surface lipoprotein is essential for the Lyme disease spirochete’s initial phase of vertebrate infection. Bacteria within the midguts of unfed ticks do not express OspC, but produce high levels when ticks begin to ingest blood. Lyme disease spirochetes cease production of OspC within 1-2 weeks of vertebrate infection, and bacteria that fail to downregulate OspC are cleared by host antibodies. Thus,...

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Literature Corpus work: a3b29691-8142-516a-90d1-62ca6813a58b
DOI: 10.1101/2022.11.09.515855

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