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Article

YebC regulates variable surface antigen VlsE expression and is required for host immune evasion in Borrelia burgdorferi.

PLoS pathogens - 1 Oct 2020

Zhang Yan, Chen Tong, Raghunandanan Sajith, Xiang Xuwu, Yang Jing, Liu Qiang, Edmondson Diane G, Norris Steven J, Yang X Frank, Lou Yongliang

Abstract excerpt

Borrelia burgdorferi, the Lyme disease pathogen causes persistent infection by evading the host immune response. Differential expression of the surface-exposed lipoprotein VlsE that undergoes antigenic variation is a key immune evasion strategy employed by B. burgdorferi. Most studies focused on the mechanism of VlsE antigen variation, but little is known about VlsE regulation and factor(s) that regulates...

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Identifiers

PMID: 33048986
DOI: 10.1371/journal.ppat.1008953
PMCID: PMC7584230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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