Article

Astragaloside IV Reduces Mutant Ataxin-3 Levels and Supports Mitochondrial Function in Spinocerebellar Ataxia Type 3

2023-09-20

Abstract excerpt

<title>Abstract</title> <p>This study investigated the effects of astragaloside IV (AST) on the neurodegenerative disease of spinocerebellar ataxia type 3 (SCA3). Human neuroblastoma SK-N-SH cells expressing mutant ataxin-3 protein with 78 CAG repeats (MJD78) were used as an in vitro model, and SCA3 transgenic mice harboring an allele with a pathological polyglutamine tract with expanded 84 CAG repeats (SCA3 84Q)...

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Literature Corpus work: a34da0c6-f9db-57d8-8df6-5192e3501b26
DOI: 10.21203/rs.3.rs-3350835/v1

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