Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polyphenol-Rich Cinnamon Bud Extract Affects Ataxin-3 Aggregation and Ameliorates SCA3 Phenotypes Through a Dual Anti-Amyloidogenic and Antioxidant Mechanism.

Molecules (Basel, Switzerland) - 17 Jul 2026

Sciandrone Barbara, Pensotti Roberta, Ami Diletta, Saponara Alessia, Campanile Riccardo, Cassina Valeria, Natalello Antonino, Palmioli Alessandro, Airoldi Cristina, Regonesi Maria Elena

Abstract excerpt

Aberrant self-assembly of ataxin-3 (ATX3) into amyloid aggregates is a key pathological event in spinocerebellar ataxia type 3 (SCA3). Bioactive nutraceutical compounds, particularly polyphenols, have emerged as promising candidates for targeting protein aggregation and cellular stress responses associated with neurodegenerative disorders. Here, we investigated cinnamon bud extract as a natural source of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxin-3
Share to Cinnamates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Machado-Joseph Disease

Share to Neuroprotective Agents

Share to Plant Extracts

Share to Polyphenols

Share to Protein Aggregates

Share to Protein Aggregation, Pathological

Source

Open in PubMed Open full text

Identifiers

PMID: 42513188
DOI: 10.3390/molecules31142510
PMCID: PMC13415171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polyphenol-Rich Cinnamon Bud Extract Affects Ataxin-3 Aggregation and Ameliorates SCA3 Phenotypes Through a Dual Anti-Amyloidogenic and Antioxidant Mechanism.PMID 42513188Read ↗

Trehalose prevents the formation of aggregates of mutant ataxin-3 and reduces soluble ataxin-3 protein levels in an SCA3 cell model.Semantic proximity Read ↗

Astragaloside IV reduces mutant Ataxin-3 levels and supports mitochondrial function in Spinocerebellar Ataxia Type 3.Semantic proximity Read ↗

Oolonghomobisflavans from <i>Camellia sinensis</i> disaggregate tau fibrils across Alzheimer’s disease modelsSemantic proximity Read ↗

Small Molecules Inducing Autophagic Degradation of Expanded Polyglutamine Protein through Interaction with Both Mutant ATXN3 and LC3.Semantic proximity Read ↗

Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity.Semantic proximity Read ↗

Astragaloside IV Reduces Mutant Ataxin-3 Levels and Supports Mitochondrial Function in Spinocerebellar Ataxia Type 3Semantic proximity Read ↗

Discovery of Isobavachin, a natural flavonoid, as an Apolipo-protein E4 (ApoE4) structure corrector for Alzheimer’s diseaseSemantic proximity Read ↗

Cryptotanshinione Inhibits β-Amyloid Aggregation and Protects Damage from β-Amyloid in SH-SY5Y CellsSemantic proximity Read ↗

Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.Semantic proximity Read ↗

Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer’s DiseaseSemantic proximity Read ↗

Natural Plant Extracts Rescue Memory Deficits in Drosophila Neurodegeneration Models.Semantic proximity Read ↗

Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and Preserves Proteostasis and BehaviorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.