Single-cell phenotype-associated subpopulation identification via transfer foundation model and statistical ensemble learning.

Abstract excerpt

BACKGROUND: Single-cell RNA sequencing (scRNA-seq) enables the characterization of cell types, states, and lineages within heterogeneous tissues, thereby providing unprecedented opportunities to dissect cellular heterogeneity. However, single-cell data alone cannot directly establish cell-phenotype relationships, which pose major challenges in linking cellular heterogeneity to complex traits and disease outcomes....

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