Article

Senolytics restore hematopoietic stem cell function in sickle cell disease

2025-02-09

Abstract excerpt

Sickle Cell Disease (SCD) is a blood disorder affecting millions worldwide. Emerging evidence reveals that SCD pathophysiology increases risk of myeloid malignancies and hematopoietic stem cell (HSC) dysfunction, possibly due to pathological stress on bone marrow. To investigate this further, we interrogated mice and individuals with SCD and observed extended cell cycle times, oxidative stress, DNA damage, senesce...

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Literature Corpus work: a334ff1f-e23e-59a2-8e37-ec0c60b001a9
DOI: 10.1101/2025.02.08.636742

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