Article

Improved biorepository to support sickle cell disease genomics and clinical research: A practical approach to link patient data and biospecimens from Muhimbili Sickle Cell Program, Tanzania

2023-01-09

Abstract excerpt

Genetic modifiers underlying various sickle cell disease phenotypic expressions are largely unexplored in Africa due to lack of databases linking biospecimens with demographic and clinical data. The problem may be compounded by a complete lack of biorepositories in these settings. This article aims to document the physical verification of biospecimens stored in the biorepository and link them to patient clinical a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a327e42a-2e1a-586c-a6ad-039d433b51ea
DOI: 10.1101/2023.01.06.23284272

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Improved biorepository to support sickle cell disease genomics and clinical research: A practical approach to link patient data and biospecimens from Muhimbili Sickle Cell Program, TanzaniaDOI 10.1101/2023.01.06.23284272Read

Rare diseases in Tanzania: a National Call for Action to address policy and urgent needs of individuals with rare diseasesSemantic proximity Read

A cross-sectional study of the clinical manifestations of Sickles Cell Disease in Ghana, Nigeria and Tanzania and its association with foetal haemoglobin parametersSemantic proximity Read

Clinical and genetic ancestry profile of a large multi-centre sickle cell disease cohort in Brazil.Semantic proximity Read

Sickle Cell Disease Demographics and Clinical Epidemiology in Gambian Urban and Rural Cohorts Retrospective AnalysisSemantic proximity Read

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in Sickle Cell Disease in Tanzania.Semantic proximity Read

Accurate identification of sickle cell disease cases in a large genotyped cohort using electronic health record data.Semantic proximity Read

Updated Worldwide Epidemiology of Inherited Erythrocyte DisordersSemantic proximity Read

Genetics and Genomics in Sickle Cell Disease in Africa.Semantic proximity Read

An Analysis of Racial and Ethnic Backgrounds Within the CASiRe International Cohort of Sickle Cell Disease Patients: Implications for Disease Phenotype and Clinical Research.Semantic proximity Read

Prenatal diagnosis of sickle cell disease by amniocentesis using FTA technology in a context of precariousness in sub-Saharan Africa: Challenges and perspectivesSemantic proximity Read

Prospective Newborn Screening for Sickle Cell Disease and Other Inherited Blood Disorders in Central MalawiSemantic proximity Read

Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients.Semantic proximity Read