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Alphavirus-induced transcriptional and translational shutoffs play major roles in blocking the formation of stress granules

30 Oct 2023

Abstract excerpt

ABSTRACT Alphavirus infections cause multiple alterations in the intracellular environment that can have both positive and negative effects on viral replication. The Old World alphaviruses, such as Sindbis (SINV), chikungunya (CHIKV), and Semliki Forest viruses, hinder the ability of vertebrate cells to form stress granules (SGs). Previously, this inhibitory function was attributed to the hypervariable domain...

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PMID: 37902397
DOI: 10.1128/jvi.00979-23

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