Article

Identifying <i>Streptococcus pneumoniae</i> genes associated with invasive disease using pangenome-based whole genome sequence typing

2018-05-04

Abstract excerpt

Streptococcus pneumoniae is a normal commensal of the upper respiratory tract but can also invade the bloodstream or CSF (cerebrospinal fluid), causing invasive pneumococcal disease (IPD). In this study, we attempt to identify genes associated with IPD by applying a random forest machine-learning algorithm to whole genome sequence (WGS) data. We find 43 genes consistently associated with IPD across three geographi...

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Literature Corpus work: 3d4eec8c-2938-553a-abb0-828f9af193a8
DOI: 10.1101/314666

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