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Article

Binding Interaction Between Two Mutant Myocilin Olfactomedin Domain Monomers in a Homodimer.

The journal of physical chemistry. B - 5 Dec 2024

Rahman Aziza, Saikia Bondeepa, Baruah Anupaul

Abstract excerpt

In myocilin-associated glaucoma, pathogenic missense mutations accumulate mainly in the olfactomedin domain (mOLF) of myocilin. This makes the protein susceptible to aggregation, where mOLF-mOLF dimerization is possibly an initial stage. Nevertheless, there are no molecular level studies that have probed the nature of interactions occurring between two mOLF domains and the key characteristics of the resulting...

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Identifiers

PMID: 39571175
DOI: 10.1021/acs.jpcb.4c06782

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