Back to search

Article

A Computational Model for the Evaluation of Complement System Regulation under Homeostasis, Disease, and Drug Intervention

2017-11-25

Abstract excerpt

<h4>Highlights</h4> Computational model describing dynamics of complement system activation pathways Complement dysregulation leads to deviation from homeostasis and to inflammatory diseases Model identifies biomarkers to quantify the effects of complement dysregulation Known drugs restore impaired dynamics of complement biomarkers under dysregulation Disease-specific models are suitable for diagnosis and patient...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a2918112-4f6e-5e3a-ac3a-a9341b729117
DOI
10.1101/225029
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Computational Model for the Evaluation of Complement System Regulation under Homeostasis, Disease, and Drug InterventionDOI 10.1101/225029
A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug interventionSemantic proximity
Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and diseaseSemantic proximity
Therapeutic Lessons to be Learned From the Role of Complement Regulators as Double-Edged Sword in Health and DiseaseSemantic proximity
Complement dysregulation and disease: from genes and proteins to diagnostics and drugs.Semantic proximity
Complement Factor I Deficiency, a study on prevalence and impacts on complement dysregulation and health.Semantic proximity
Complement‐targeted therapeutics: An emerging field enabled by academic drug discoverySemantic proximity
European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management.Semantic proximity
Tipping the balance: intricate roles of the complement system in disease and therapySemantic proximity
Complement biology for hematologistsSemantic proximity
Diseases of complement dysregulation-an overview.Semantic proximity
Review: The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune DiseasesSemantic proximity
Complement‐targeted therapeutics: Are we there yet, or just getting started?Semantic proximity
Select a neighboring publication to make it the new centre.