Article

HIV-1 Amplifies IL-8 Response of Human Stellate Cells to Gram-Positive Microbial Products Via H4K5 Histone Acetylation

2025-05-15

Abstract excerpt

<h4>Background</h4> Patients living with human immunodeficiency virus 1 (PLWH) develop accelerated liver fibrosis, but the exact mechanism remains unknown. Activation of hepatic stellate cells (HSCs)—a cornerstone of fibrosis—is influenced by various factors, including viral infection, hepatocellular injury, chronic immune activation, gut barrier dysfunction, and microbial translocation. The role of gram-positive...

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Literature Corpus work: a2541089-668c-5d67-8a58-014f405f6dc1
DOI: 10.1101/2025.05.12.653460

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