Illuminating the Ligandable Human Proteome with AI Protein Profiling

Abstract excerpt

Most human proteins lack chemical probes or pharmaceutical modulators, leaving much of the proteome unexplored. 1,2 Activity-based protein profiling has enabled proteome-scale discovery of protein-ligand interactions and covalent inhibitors, 3–5 but remains limited by probe chemistry, protein abundance, and discordant ligandability assignments across studies. 6–9 Machine-learning (ML) models can in principle ge...

Topics

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• Binding Sites
• Computational Drug Discovery Methods
• Deep Learning
• Mutation
• Protein Binding
• Protein Degradation and Inhibitors
• Repressor Proteins
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

a23b1d94-51ca-5eee-8d38-d3fdd410596f

DOI

10.1101/2025.09.07.670677