Article

Fluorescent in situ hybridization is a deceptive method for screening NRG1 gene rearrangements

2022-12-19

Abstract excerpt

<h4>Background: </h4> NRG1 rearrangement has been identified in many tumors and is considered an important treatment target. However, the prevalence of NRG1 fusion is extremely rare, and there are no universal testing algorithms for genetic testing. Methods A total of 3008 cases of various kinds of tumors were included in this study. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) were us...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a235b81f-365c-5646-8d7a-43d763215779
DOI: 10.21203/rs.3.rs-2381021/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fluorescent in situ hybridization is a deceptive method for screening NRG1 gene rearrangementsDOI 10.21203/rs.3.rs-2381021/v1Read

Expert Consensus on the Diagnosis and Treatment of NRG1/2 Gene Fusion Solid TumorsSemantic proximity Read

Detection of NRG1 Gene Fusions in Solid TumorsSemantic proximity Read

RNA Sequencing Identifies Novel NRG1 Fusions in Solid Tumors that Lack Co-Occurring Oncogenic DriversSemantic proximity Read

NRG1 Gene Fusions—What Promise Remains Behind These Rare Genetic Alterations? A Comprehensive Review of Biology, Diagnostic Approaches, and Clinical ImplicationsSemantic proximity Read

Characterizing the molecular and clinical implications of NRG1 fusions in NSCLC through integrated RNA and DNA sequencing analysis.Semantic proximity Read

Comparative Analysis of Molecular Testing Methods for FGFR2 Fusion/Rearrangement in Intrahepatic CholangiocarcinomaSemantic proximity Read

The Genomic Profiling in Chinese Head and Neck Cancer and Incidence of NTRK FusionSemantic proximity Read

Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicineSemantic proximity Read

Detection of NTRK Fusions: Merits and Limitations of Current Diagnostic PlatformsSemantic proximity Read

Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary GlandsSemantic proximity Read

NRG1 Fusions in Breast CancerSemantic proximity Read

Integrated Evaluation of TRK Expression in Gastric Adenocarcinoma: Correlation with Immunohistochemistry- and In Situ Hybridization–Based Molecular Classification and Diagnostic ChallengesSemantic proximity Read