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Expert Consensus on the Diagnosis and Treatment of NRG1/2 Gene Fusion Solid Tumors

1 Jan 2024

Abstract excerpt

The fusion genes NRG1 and NRG2 , members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, NRG1 retains its EGF-like active domain, binds to the ERBB ligand family, and triggers intracellular signaling cascades, promoting uncontrolled cell proliferation. The incidence of NRG1 gene fusion varies across cancer types, with lung cancer being the most prevalent...

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HER2/EGFR in Cancer Research
Lung Cancer Treatments and Mutations
Monoclonal and Polyclonal Antibodies Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38414979
DOI: 10.1055/s-0044-1781457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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