Article

NRG1 Fusions in Breast Cancer

2020-09-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> <italic>NRG1 </italic>gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors. The <italic>NRG1</italic> gene encodes ligands for the HER2(ERBB2)-ERBB3 heterodimeric receptor tyrosine kinase, and the gene fusions are thought to lead to autocrine stimulation of the receptor. The <itali...

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Literature Corpus work: 08828518-91c1-5e0d-a4e7-3c4296f3e67a
DOI: 10.21203/rs.3.rs-75553/v1

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