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Teriflunomide Promotes Blood-Brain Barrier Integrity by Upregulating Claudin-1 via the Wnt/β-catenin Signaling Pathway in Multiple Sclerosis

2022-09-02

Abstract excerpt

<h4>Background: </h4> ： The blood-brain barrier (BBB) and tight junction (TJ) proteins maintain the homeostasis of the central nervous system (CNS). The dysfunction of BBB allows peripheral T cells infiltration into CNS and contributes to the pathophysiology of multiple sclerosis (MS). Teriflunomide is an approved drug for the treatment of MS by suppressing lymphocytes proliferation. However, whether teriflunomide...

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Literature Corpus work
a200a5c2-d77e-58dc-b1bc-413987303ecc
DOI
10.21203/rs.3.rs-2004378/v1
Open publication

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Teriflunomide Promotes Blood-Brain Barrier Integrity by Upregulating Claudin-1 via the Wnt/β-catenin Signaling Pathway in Multiple SclerosisDOI 10.21203/rs.3.rs-2004378/v1
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