Flecainide enhances blood-brain barrier function: Novel mode of action of sodium channel blocking in experimental autoimmune encephalomyelitis (EAE) 

Abstract excerpt

<title>Abstract</title> <p>Introduction Multiple Sclerosis (MS), an autoimmune disorder, is characterized by severe neuroinflammation, leading to demyelination and neuronal damage in the CNS, resulting in significant clinical impairment. MS progression involves complex pathological processes like immune cell invasion and cytokine-mediated recruitment to the CNS. Experimental autoimmune encephalomyelitis (EAE), a...

Topics

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• Cytokine Signaling Pathways and Interactions
• Drug Therapy
• Endoplasmic Reticulum Stress and Disease
• Immune Cell Function and Interaction
• Multiple Sclerosis
• Phenotype
• Practice Guidelines as Topic
• United States

Identifiers and source

Literature Corpus work

46f099cb-0c2c-5805-a395-0a96c7ca7dab

DOI

10.21203/rs.3.rs-4835767/v1