Article
Tetramethylpyrazine Protects Blood-Spinal Cord Barrier Integrity by Modulating Microglia Polarization Through Activation of STAT3/SOCS3 and Inhibition of NF-кB Signaling Pathways in Experimental Autoimmune Encephalomyelitis Mice.
Cellular and molecular neurobiology - 1 May 2021
Zhang Lianshuang, Lu Xueyan, Gong Lihua, Cui Linlu, Zhang Hongqin, Zhao Wei, Jiang Pengyu, Hou GuiGe, Hou Yun
Abstract excerpt
We previously reported that tetramethylpyrazine (TMP) alleviates experimental autoimmune encephalomyelitis (EAE) by decreasing glia activation. Activated microglia has been shown to mediate blood-spinal cord barrier (BSCB) disruption, which is a primary and continuous pathological characteristic of multiple sclerosis (MS). Therefore, in this study, we further investigated whether TMP protects the BSCB integrity...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.