Article

Modeling Microbiome Modulation of Tumor Metabolic Networks to Predict Synergistic Therapies

2026-02-26

Abstract excerpt

Differences in microbiome composition profoundly influence drug response, yet methods to model the metabolic interplay between tumors, microbes, and therapeutics remain limited. We present a generalizable framework combining machine-learning and genome-scale metabolic modeling to prioritize combination therapies for colorectal cancer (CRC) in the presence of Fusobacterium nucleatum ( Fn ) and other pathogenic, p...

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Literature Corpus work: a1be7aec-e771-5af7-87cd-efc11ced42bc
DOI: 10.64898/2026.02.25.707963

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