Article

Computational metabolic modeling unveils gut microbiome’s role in metabolic shifts during murine cancer cachexia

2024-09-13

Abstract excerpt

Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss, muscle wasting, systemic inflammation, and metabolic alterations, affecting up to 87% of pancreatic and gastric cancer patients. Unlike simple starvation, cachexia is driven by metabolic disruption involving both host physiology and the gut microbiome. While microbiome changes in cachexia have been documented, a coherent underst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: daf26b63-3e18-5764-950b-c847732bcc30
DOI: 10.1101/2024.09.13.612865

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational metabolic modeling unveils gut microbiome’s role in metabolic shifts during murine cancer cachexiaDOI 10.1101/2024.09.13.612865Read

Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patientsSemantic proximity Read

Metabolic modeling and functional genomics reveal taxa and host gene interactions in colorectal cancerSemantic proximity Read

Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An OverviewSemantic proximity Read

MICOMWeb: a website for microbial community metabolic modeling of the human gutSemantic proximity Read

Fecal Microbiome Composition and Plasma Metabolomics in Pancreatic Cancer Cachexia Treated with Nutritional SupportSemantic proximity Read

Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancerSemantic proximity Read

Ensemble-based genome-scale modeling predicts metabolic differences between macrophage subtypes in colorectal cancerSemantic proximity Read

Modeling metabolism of the human gut microbiomeSemantic proximity Read

Modeling Microbiome Modulation of Tumor Metabolic Networks to Predict Synergistic TherapiesSemantic proximity Read

Gut bacterial nutrient preferences quantified in vivoSemantic proximity Read

Modeling approaches for probing cross-feeding interactions in the human gut microbiomeSemantic proximity Read

Cancer-associated fibroblasts drive metabolic heterogeneity in colorectal cancer cells: predictions from metabolic modeling.Semantic proximity Read