Article

Genetic analysis of female genital tract polyps implicates genome stability, estrogen signalling and shared susceptibility with proliferative gynaecological disorders

2026-04-16

Abstract excerpt

Female genital tract (FGT) polyps are common benign growths affecting up to half of all women. However, they carry malignant potential, and their genetic architecture remains poorly defined. We conducted a genome-wide association study (GWAS) meta-analysis across four biobanks (48,400 cases, 477,134 controls), identifying 26 risk loci for FGT polyps, 12 of which were previously unreported. Integrative gene priorit...

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Literature Corpus work: a1b6a359-d724-5e8c-b8db-8eec66611d97
DOI: 10.64898/2026.04.13.26350740

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