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Article

Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from Pseudomonas aeruginosa.

mBio - 23 Feb 2021

Li Tao, Song Yingjie, Luo Liming, Zhao Ninglin, He Lihui, Kang Mei, Li Changcheng, Zhu Yibo, Shen Yalin, Zhao Chang, Yang Jing, Huang Qin, Mou Xingyu, Zong Zhiyong, Yang Jinliang, Tang Hong, He Yongxing, Bao Rui

Abstract excerpt

AlgW, a membrane-bound periplasmic serine protease belonging to the HtrA protein family, is a key regulator of the regulated intramembrane proteolysis (RIP) pathway and is responsible for transmitting the envelope stress signals in Pseudomonas aeruginosa The AlgW PDZ domain senses and binds the C-terminal of mis-localized outer membrane proteins (OMPs) or periplasmic protein MucE, leading to catalytic activation...

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Share to Bacterial Outer Membrane Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33622718
DOI: 10.1128/mBio.03299-20
PMCID: PMC8545111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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