Article

PEPSI: Polarity measurements from spatial proteomics imaging suggest immune cell engagement

2023-10-17

Abstract excerpt

Subcellular protein localization is important for understanding functional states of cells, but measuring and quantifying this information can be difficult and typically requires high-resolution microscopy. In this work, we develop a metric to define surface protein polarity from immunofluorescence (IF) imaging data and use it to identify distinct immune cell states within tumor microenvironments. We apply this me...

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Literature Corpus work: a187abdd-8a72-5073-8c39-3891be76c8e5
DOI: 10.1101/2023.10.13.562299

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