Article

Combined effects of restriction factors and transduction adjuvants on lentiviral vector gene transfer efficacy

2025-06-30

Abstract excerpt

<title>Abstract</title> <p>Restriction factors include various cellular proteins that detect and impede viral infections. Among them, interferon-induced transmembrane (IFITM) and serine incorporator (SERINC) proteins interfere with the infectious cycle of HIV-1. Consequently, such restriction factors can also interfere with gene transfer efficacy when using recombinant lentiviral vectors derived from HIV-1, but t...

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Literature Corpus work: a15d3d0a-943d-5356-be4c-fbe26479b928
DOI: 10.21203/rs.3.rs-6702056/v1

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