Article

Translational Development of A Tumor Junction Opening Technology

2021-11-24

Abstract excerpt

Our goal is to overcome treatment resistance in ovarian cancer patients, which occurs in most cases after an initial positive response to chemotherapy. A central resistance mechanism is the maintenance of desmoglein-2 (DSG2)-positive tight junctions between malignant cells, which prevents drug penetration into the tumor. We generated JO4, a recombinant protein that binds to DSG2, resulting in the transient opening...

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Literature Corpus work: a1272a58-5a4e-5f5c-bbeb-585e8c731eda
DOI: 10.21203/rs.3.rs-1075411/v1

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