Article

Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism

2020-03-09

Abstract excerpt

The crucial transmission phase of tuberculosis (TB) relies on infectious sputum yet cannot easily be modeled. We applied one-step RNA-Sequencing to sputum from infectious TB patients to investigate the host and microbial environments underlying transmission of Mycobacterium tuberculosis ( Mtb ). In such TB sputa, compared to non-TB controls, transcriptional upregulation of inflammatory responses and a metabolic...

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Literature Corpus work: a10fb08f-b3cf-5900-9aac-d31b9b0ae98c
DOI: 10.1101/2020.03.09.983163

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