Back to search

Article

The interplay between splicing of exons 18a and 47 differentially affects membrane targeting and function of human Ca <sub>V</sub> 2.2

2023-09-15

Abstract excerpt

N-type calcium channels (Ca V 2.2) are predominantly localized in presynaptic terminals, and are particularly important for pain transmission in the spinal cord. Furthermore, they have multiple isoforms, conferred by alternatively-spliced or cassette exons, which are differentially expressed. Here we have examined alternatively-spliced exon47 variants that encode a long or short C-terminus in human Ca V 2.2. In...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a0cf432c-2682-5ad9-bba5-949ae4fef68a
DOI
10.1101/2023.09.15.557884
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The interplay between splicing of exons 18a and 47 differentially affects membrane targeting and function of human Ca <sub>V</sub> 2.2DOI 10.1101/2023.09.15.557884
Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit.Semantic proximity
Ca(V)2.1 P/Q-type calcium channel alternative splicing affects the functional impact of familial hemiplegic migraine mutations: implications for calcium channelopathies.Semantic proximity
A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies.Semantic proximity
A structural analysis of the splice-specific functional impact of the pathogenic familial hemiplegic migraine type 1 S218L mutation on Cav2.1 P/Q-type channel gating.Semantic proximity
Developmental and cell-specific expression of <i>Cacna1d</i> splice variantsSemantic proximity
Epigenetic control of ion channel expression and cell-specific splicing in nociceptors: Chronic pain mechanisms and potential therapeutic targetsSemantic proximity
Splice-variant specific effects of a CACNA1H mutation associated with writer’s crampSemantic proximity
Cell-specific exon methylation and CTCF binding in neurons regulates calcium ion channel splicing and functionSemantic proximity
Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating.Semantic proximity
Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: functional differences are beta subunit-specific.Semantic proximity
Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations.Semantic proximity
Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles.Semantic proximity
Select a neighboring publication to make it the new centre.