Article

Copy number gain of CMTM6 increases the expression of PD-L1 in undifferentiated pleomorphic sarcoma

2021-02-10

Abstract excerpt

<title>Abstract</title> <p>Background Undifferentiated pleomorphic sarcoma (UPS) is a sarcoma with a poor prognosis. A clinical trial, SARC028, revealed that treatment with anti-PD-1 drugs was effective against UPS. Studies have reported that UPS expresses PD-L1, sometime strongly (≥ 50%). However, the mechanism of PD-L1 expression in UPS has remained still unclear. CKLF-like MARVEL transmembrane domain containi...

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Literature Corpus work: a0c08fe6-7e2f-5671-b30b-c0a2bfdacf85
DOI: 10.21203/rs.3.rs-201625/v1

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