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Article

Recurrent <i>PRDM10</i> Gene Fusions in Undifferentiated Pleomorphic Sarcoma

16 Dec 2014

Abstract excerpt

PURPOSE: Undifferentiated pleomorphic sarcoma (UPS) is defined as a sarcoma with cellular pleomorphism and no identifiable line of differentiation. It is typically a high-grade lesion with a metastatic rate of about one third. No tumor-specific rearrangement has been identified, and genetic markers that could be used for treatment stratification are lacking. We performed transcriptome sequencing (RNA-Seq) to...

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PMID: 25516889
DOI: 10.1158/1078-0432.ccr-14-2399

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