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Article

Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile

17 Jul 2019

Abstract excerpt

Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive soft tissue tumor. A subset of UPS is characterized by a CITED2-PRDM10 or a MED12-PRDM10 gene fusion. Preliminary data suggest that these so-called PRDM10-rearranged tumors (PRT) are clinically more indolent than classical high-grade UPS, and hence important to recognize. Here, we assessed the spectrum of accompanying mutations and the gene...

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PMID: 31313299
DOI: 10.1002/path.5326

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