Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA‐seq analysis of ageing human retinal pigment epithelium: Unexpected up‐regulation of visual cycle gene transcription

1 May 2021

Abstract excerpt

Abstract Ageing presents adverse effects on the retina and is the primary risk factor for age‐related macular degeneration (AMD). We report the first RNA‐seq analysis of age‐related transcriptional changes in the human retinal pigment epithelium (RPE), the primary site of AMD pathogenesis. Whole transcriptome sequencing of RPE from human donors ranging in age from 31 to 93 reveals that ageing is associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments
Share to Retinal Imaging and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33934486
DOI: 10.1111/jcmm.16569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA‐seq analysis of ageing human retinal pigment epithelium: Unexpected up‐regulation of visual cycle gene transcriptionPMID 33934486Read ↗

Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degenerationSemantic proximity Read ↗

Dynamic human retinal pigment epithelium (RPE) and choroid architecture based on single-cell transcriptomic landscape analysisSemantic proximity Read ↗

An Integrated Multi-omics Single Cell Atlas of the Human RPE and ChoroidSemantic proximity Read ↗

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degenerationSemantic proximity Read ↗

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration.Semantic proximity Read ↗

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networksSemantic proximity Read ↗

Intercellular communication analysis of the human retinal pigment epithelial and choroidal cells predicts pathways associated with aging, cellular senescence and age-related macular degenerationSemantic proximity Read ↗

Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single-cell RNA sequencing study to understand age-related macular degenerationSemantic proximity Read ↗

A New Strategy to Identify and Annotate Human RPE-Specific Gene ExpressionSemantic proximity Read ↗

Integrative single-cell and bulk RNA-seq analysis in human retina identified cell type-specific composition and gene expression changes for age-related macular degenerationSemantic proximity Read ↗

Retinal Aging Transcriptome and Cellular Landscape in Association With the Progression of Age-Related Macular DegenerationSemantic proximity Read ↗

Implication of specific retinal cell-type involvement and gene expression changes in AMD progression using integrative analysis of single-cell and bulk RNA-seq profilingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.