Article
Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene.
Stem cell research - 1 Sept 2023
Montero-Calle Pilar, Flandes-Iparraguirre María, Kuebler Bernd, Arán Begoña, Larequi Eduardo, Anaut Ilazki, Coppiello Giulia, Aranguren Xabier L, Veiga Anna, Elorz Maria Teresa Basurte, de Yébenes Manuel García, Gavira Juan J, Prósper Felipe, Iglesias-García Olalla, Vega Manuel M Mazo
Abstract excerpt
Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linked to cardiac toxicity and progression toward heart failure. A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) from...
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